Voriconazole is a broad-spectrum triazole antifungal raw material, appearing as white or off-white crystalline powder. Its chemical name is (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol. This product features high efficacy, low toxicity and strong tissue penetration with high bioavailability, serving as a first-line drug for the treatment of severe invasive fungal infections.
Physical & Chemical Properties
Molecular FormulaC16H14F3N5O
Density:g/cm³
Boiling Point:
Solubility:
Soluble in methanol, acetonitrile and DMSO; sparingly soluble in ethanol; practically insoluble in water.
Molecular Weight:349.31g/mol
Flash Point:
Melting Point:127-130℃
Uses
1. Core clinical application: First-line therapy for invasive aspergillosis.
2. Candida infections: Candidemia, esophageal candidiasis and drug-resistant Candida infections in non-neutropenic patients.
3. Rare fungi: Treatment of severe infections caused by Scedosporium, Fusarium and other pathogens.
4. Prophylaxis: Prevention of fungal infections in immunocompromised patients (e.g., chemotherapy recipients, transplant patients).